InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFP36L2

Summary

InnateDB Protein

IDBP-48690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFP36L2

Protein Name

zinc finger protein 36, C3H type-like 2

Synonyms

BRF2; ERF-2; ERF2; RNF162C; TIS11D;

Species

Homo sapiens

Ensembl Protein

ENSP00000282388

InnateDB Gene

IDBG-48686 (ZFP36L2)

Protein Structure

UniProt Annotation

Function

mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity). {ECO:0000250, ECO:0000269PubMed:14981510}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Disease Associations

Note=Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been found in a patient with acute myeloid leukemia (PubMed:21109922). {ECO:0000269PubMed:21109922}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0017091	AU-rich element binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006355	regulation of transcription, DNA-templated
GO:0006402	mRNA catabolic process
GO:0008283	cell proliferation
GO:0030097	hemopoiesis
GO:0033077	T cell differentiation in thymus
GO:0035019	somatic stem cell maintenance
GO:0043488	regulation of mRNA stability
GO:0048103	somatic stem cell division
GO:0060216	definitive hemopoiesis
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000737	negative regulation of stem cell differentiation