Version 5.4
Homo sapiens Gene: SPRED3
Summary
InnateDB Gene IDBG-48780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRED3
Gene Name sprouty-related, EVH1 domain containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188766
Encoded Proteins
IDBP-48782
sprouty-related, EVH1 domain containing 3
IDBP-765065
IDBP-763665
IDBP-762958
IDBP-763475
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38388421-38396241
Strand Forward strand
Band q13.2
Transcripts
ENST00000338502 ENSP00000345405
ENST00000587947 ENSP00000467532
ENST00000587013 ENSP00000467540
ENST00000586301 ENSP00000466568
ENST00000587564
ENST00000590962
ENST00000586958 ENSP00000465713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037239
View Gene Order
ENSBTAG00000017678
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001042522 XM_006723219
HUGO
OMIM
CCDS CCDS42560
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca