Mus musculus Gene: Spred3
Summary
InnateDB Gene IDBG-166162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spred3
Gene Name sprouty-related, EVH1 domain containing 3
Synonyms AW047143; D130060H24Rik; Spred-3
Species Mus musculus
Ensembl Gene ENSMUSG00000037239
Encoded Proteins
sprouty-related, EVH1 domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188766:
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:29158829-29169841
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000048923 ENSMUSP00000046216
ENSMUST00000130390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q6P6N5
TrEMBL
UniProt Splice Variant
Entrez Gene 101809
UniGene Mm.377262 Mm.455398 Mm.462601 Mm.484186
RefSeq NM_182927 XM_006539451 XM_006539452 XM_006539453 XM_006539454 XM_006539455 XM_006539456
OMIM
CCDS CCDS21065
HPRD
IMGT
MGI ID MGI:2142186
MGI Symbol Spred3
EMBL AB115762 BC062119
GenPept AAH62119 BAC80222
RNA Seq Atlas 101809