Version 5.4
Homo sapiens Gene: NETO1
Summary
InnateDB Gene IDBG-4880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NETO1
Gene Name neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166342
Encoded Proteins
IDBP-4882
neuropilin (NRP) and tolloid (TLL)-like 1
IDBP-234266
neuropilin (NRP) and tolloid (TLL)-like 1
IDBP-728044
IDBP-727790
IDBP-727416
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:72742314-72868146
Strand Reverse strand
Band q22.3
Transcripts
ENST00000327305 ENSP00000313088
ENST00000397929 ENSP00000381024
ENST00000582281 ENSP00000462993
ENST00000579730
ENST00000583169 ENSP00000464312
ENST00000577184
ENST00000579169 ENSP00000464188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0007613 memory
GO:0008542 visual learning
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0097120 receptor localization to synapse
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005576 extracellular region
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0032983 kainate selective glutamate receptor complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050321
View Gene Order
ENSBTAG00000012889
Not yet available
Cross-References
SwissProt Q8TDF5
TrEMBL A0A024R375
UniProt Splice Variant
Entrez Gene 81832
UniGene
RefSeq NM_001201465 XM_006722553 NM_138966 NM_138999 XM_005266773
HUGO HGNC:13823
OMIM 607973
CCDS CCDS12000 CCDS42444
HPRD 16264
IMGT
EMBL AC023301 AC091138 AF448838 AF448839 AL834354 BC050329 CH471117
GenPept AAH50329 AAM18026 AAM18027 CAD39019 EAW66530 EAW66531
RNA Seq Atlas 81832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca