Version 5.4
Mus musculus Gene: Lime1
Summary
InnateDB Gene IDBG-488854.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lime1
Gene Name Lck interacting transmembrane adaptor 1
Synonyms 2810038K19Rik; LIME
Species Mus musculus
Ensembl Gene ENSMUSG00000090077
Encoded Proteins
IDBP-214092
Lck interacting transmembrane adaptor 1
IDBP-263755
Lck interacting transmembrane adaptor 1
IDBP-532512
Lck interacting transmembrane adaptor 1
IDBP-538027
Lck interacting transmembrane adaptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203896:
LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells (Brdickova et al., 2003 [PubMed 14610046]; Hur et al., 2003 [PubMed 14610044]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181380078-181383628
Strand Forward strand
Band H4
Transcripts
ENSMUST00000048077 ENSMUSP00000045010
ENSMUST00000108804 ENSMUSP00000104432
ENSMUST00000140943 ENSMUSP00000117558
ENSMUST00000126611 ENSMUSP00000119181
ENSMUST00000126862
ENSMUST00000126733
ENSMUST00000184328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043405 regulation of MAP kinase activity
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051279 regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0016021 integral component of membrane
GO:0019815 B cell receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000203896
View Gene Order
ENSBTAG00000007501
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9EQR5
TrEMBL A2AU24 Q3T9B9
UniProt Splice Variant
Entrez Gene 72699
UniGene Mm.440138
RefSeq NM_023684
OMIM
CCDS CCDS17211
HPRD
IMGT
MGI ID MGI:1919949
MGI Symbol Lime1
EMBL AF115339 AK172632 AL928965 BC023065 CH466626
GenPept AAG35210 AAH23065 BAE43105 EDL07413
RNA Seq Atlas 72699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca