Version 5.4
Homo sapiens Gene: AGPAT3
Summary
InnateDB Gene IDBG-4929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGPAT3
Gene Name 1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160216
Encoded Proteins
IDBP-4931
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-4933
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-233943
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-233945
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-233947
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-369485
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-369500
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-369506
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-369511
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-369513
1-acylglycerol-3-phosphate O-acyltransferase 3
IDBP-602888
1-acylglycerol-3-phosphate O-acyltransferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:43865186-43986536
Strand Forward strand
Band q22.3
Transcripts
ENST00000327505 ENSP00000332989
ENST00000291572 ENSP00000291572
ENST00000398063 ENSP00000381140
ENST00000398061 ENSP00000381138
ENST00000398058 ENSP00000381135
ENST00000448287 ENSP00000389318
ENST00000445582 ENSP00000412079
ENST00000457068 ENSP00000413906
ENST00000448845 ENSP00000394102
ENST00000422850 ENSP00000414440
ENST00000474735
ENST00000498670
ENST00000497909
ENST00000479117
ENST00000481319
ENST00000467358
ENST00000484865
ENST00000546158 ENSP00000443510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001211
View Gene Order
ENSBTAG00000020456
Not yet available
Pathways
NETPATH
REACTOME
REACT_120906
Synthesis of PA pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9NRZ7
TrEMBL C9J184 C9JK35 C9JL26 C9JQX8
UniProt Splice Variant
Entrez Gene 56894
UniGene Hs.248785 Hs.604358 Hs.605142 Hs.609467 Hs.623312 Hs.736967 Hs.738662
RefSeq NM_001037553 NM_020132 XM_005261159 XM_005261160 XM_006724029 XM_006724030 XM_006724031
HUGO HGNC:326
OMIM 614794
CCDS CCDS13703
HPRD 10637
IMGT
EMBL AB040138 AF156774 AF156775 AK125804 AL832919 AP001053 AP001054 AY358704 BC011971 BC040603 BC063552 CH471079
GenPept AAF80336 AAF80337 AAH11971 AAH40603 AAH63552 AAQ89067 BAB18943 BAC86299 CAD38635 EAX09461 EAX09463 EAX09464 EAX09465
RNA Seq Atlas 102724054 56894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca