Version 5.4
Homo sapiens Gene: EIF3K
Summary
InnateDB Gene IDBG-49339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3K
Gene Name eukaryotic translation initiation factor 3, subunit K
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178982
Encoded Proteins
IDBP-49341
eukaryotic translation initiation factor 3, subunit K
IDBP-589481
eukaryotic translation initiation factor 3, subunit K
IDBP-599476
eukaryotic translation initiation factor 3, subunit K
IDBP-763601
IDBP-765613
IDBP-762698
IDBP-760612
IDBP-760019
IDBP-763720
IDBP-808452
eukaryotic translation initiation factor 3, subunit K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38619082-38636955
Strand Forward strand
Band q13.2
Transcripts
ENST00000248342 ENSP00000248342
ENST00000545173 ENSP00000438145
ENST00000538434 ENSP00000440999
ENST00000589307 ENSP00000464827
ENST00000593149 ENSP00000465460
ENST00000588299
ENST00000588422
ENST00000592558 ENSP00000468231
ENST00000588934 ENSP00000468525
ENST00000586932
ENST00000591409 ENSP00000467895
ENST00000586513 ENSP00000466609
ENST00000593062
ENST00000590134
ENST00000614624 ENSP00000479334
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 75 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053565
View Gene Order
ENSBTAG00000011212
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001300992 NM_013234 XM_006723147
HUGO
OMIM
CCDS CCDS12517 CCDS74360
HPRD 11740
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca