Version 5.4
Mus musculus Gene: Eif3k
Summary
InnateDB Gene IDBG-165187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif3k
Gene Name eukaryotic translation initiation factor 3, subunit K
Synonyms 1200009C21Rik; Eif3s12
Species Mus musculus
Ensembl Gene ENSMUSG00000053565
Encoded Proteins
IDBP-165189
eukaryotic translation initiation factor 3, subunit K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178982:
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28971373-28981814
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000066070 ENSMUSP00000066038
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178982
View Gene Order
ENSBTAG00000011212
Not yet available
Pathways
NETPATH
REACTOME
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_254308
Translation pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_249044
Formation of a pool of free 40S subunits pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_249316
Formation of the ternary complex, and subsequently, the 43S complex pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_203882
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_216229
Formation of a pool of free 40S subunits pathway
REACT_209048
Translation pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9DBZ5
TrEMBL
UniProt Splice Variant
Entrez Gene 73830
UniGene
RefSeq NM_028659
OMIM
CCDS CCDS21062
HPRD
IMGT
MGI ID MGI:1921080
MGI Symbol Eif3k
EMBL AK004664 BC027638 BC091749
GenPept AAH27638 AAH91749 BAB23454
RNA Seq Atlas 73830

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca