Version 5.4
Homo sapiens Gene: PVRL3
Summary
InnateDB Gene IDBG-49345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PVRL3
Gene Name poliovirus receptor-related 3
Synonyms CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3
Species Homo sapiens
Ensembl Gene ENSG00000177707
Encoded Proteins
IDBP-49347
poliovirus receptor-related 3
IDBP-480970
poliovirus receptor-related 3
IDBP-478821
poliovirus receptor-related 3
IDBP-480124
poliovirus receptor-related 3
IDBP-484195
poliovirus receptor-related 3
IDBP-480858
poliovirus receptor-related 3
IDBP-473511
poliovirus receptor-related 3
IDBP-480188
poliovirus receptor-related 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:111070071-111275563
Strand Forward strand
Band q13.13
Transcripts
ENST00000319792 ENSP00000321514
ENST00000491525 ENSP00000418691
ENST00000461477 ENSP00000418327
ENST00000485303 ENSP00000418070
ENST00000486596 ENSP00000417572
ENST00000493615 ENSP00000420579
ENST00000488016
ENST00000470618
ENST00000481766 ENSP00000420479
ENST00000478327
ENST00000485506 ENSP00000419829
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0009566 fertilization
GO:0016337 single organismal cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0016021 integral component of membrane
GO:0043296 apical junction complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022656
View Gene Order
ENSBTAG00000013769
Not yet available
Pathways
NETPATH
REACTOME
REACT_19268
Nectin/Necl trans heterodimerization pathway
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04520
Adherens junction pathway
INOH
PID NCI
nectin_pathway
Nectin adhesion pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.293917 Hs.599486 Hs.729564 Hs.736432
RefSeq NM_001243286 NM_001243288 NM_015480
HUGO
OMIM
CCDS CCDS2957 CCDS58842 CCDS58843
HPRD 08454
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca