InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PVRL3

Summary

InnateDB Protein

IDBP-49347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PVRL3

Protein Name

poliovirus receptor-related 3

Synonyms

CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000321514

InnateDB Gene

IDBG-49345 (PVRL3)

Protein Structure

UniProt Annotation

Function

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269PubMed:16216929}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269PubMed:11024295}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NQS3