Version 5.4
Homo sapiens Gene: LGALS7
Summary
InnateDB Gene IDBG-49458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS7
Gene Name lectin, galactoside-binding, soluble, 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205076
Encoded Proteins
IDBP-49460
lectin, galactoside-binding, soluble, 7
IDBP-763618
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008] The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38770971-38773492
Strand Reverse strand
Band q13.2
Transcripts
ENST00000378626 ENSP00000367891
ENST00000599035 ENSP00000472380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006915 apoptotic process
GO:0007157 heterophilic cell-cell adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P47929
TrEMBL M0R281
UniProt Splice Variant
Entrez Gene 653499
UniGene
RefSeq NM_002307
HUGO HGNC:6568
OMIM 600615
CCDS CCDS33012
HPRD
IMGT
EMBL AC022144 BC042911 BC061588 BC073743 CH471126 CR456917 L07769 U06643
GenPept AAA67899 AAA86820 AAH42911 AAH61588 AAH73743 CAG33198 EAW56817 EAW56818
RNA Seq Atlas 3963 653499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca