Version 5.4
Homo sapiens Protein: LGALS7
Summary
InnateDB Protein IDBP-49460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS7
Protein Name lectin, galactoside-binding, soluble, 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367891
InnateDB Gene IDBG-49458 (LGALS7)
Protein Structure
UniProt Annotation
Function Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. {ECO:0000269PubMed:11706006}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11706006}. Nucleus {ECO:0000269PubMed:11706006}. Secreted {ECO:0000305}. Note=May be secreted by a non-classical secretory pathway.
Disease Associations
Tissue Specificity Mainly expressed in stratified squamous epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006915 apoptotic process
GO:0007157 heterophilic cell-cell adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001079 Galectin, carbohydrate recognition domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00337
PRINTS
PIRSF
SMART SM00276
SM00908
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47929
PhosphoSite PhosphoSite-P47929
TrEMBL
UniProt Splice Variant
Entrez Gene 653499
UniGene
RefSeq NP_002298
HUGO HGNC:6568
OMIM 600615
CCDS CCDS33012
HPRD 09002
IMGT
EMBL BC042911 BC061588 BC073743 CH471126 CR456917 L07769 U06643
GenPept AAA67899 AAA86820 AAH42911 AAH61588 AAH73743 CAG33198 EAW56817 EAW56818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca