Version 5.4
Homo sapiens Gene: KRT16
Summary
InnateDB Gene IDBG-49482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT16
Gene Name keratin 16
Synonyms CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK; PC1
Species Homo sapiens
Ensembl Gene ENSG00000186832
Encoded Proteins
IDBP-49484
keratin 16
IDBP-759712
IDBP-761753
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24218583
[Mus musculus] Krt16 participates in the regulation of early inflammation and innate immunity in a broad range of settings involving skin, such as pachyonychia congenita and psoriasis.
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:41609778-41615899
Strand Reverse strand
Band q21.2
Transcripts
ENST00000301653 ENSP00000301653
ENST00000590990 ENSP00000467105
ENST00000593067 ENSP00000467124
ENST00000588319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007568 aging
GO:0008283 cell proliferation
GO:0008544 epidermis development
GO:0030336 negative regulation of cell migration
GO:0042633 hair cycle
GO:0045104 intermediate filament cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053797
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655160
RefSeq NM_005557
HUGO
OMIM
CCDS CCDS11401
HPRD 01018
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca