InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRT16

Summary

InnateDB Protein

IDBP-49484.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRT16

Protein Name

keratin 16

Synonyms

CK16; FNEPPK; K16; K1CP; KRT16A; NEPPK; PC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000301653

InnateDB Gene

IDBG-49482 (KRT16)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Pachyonychia congenita 1 (PC1) [MIM:167200]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present. {ECO:0000269PubMed:10521820, ECO:0000269PubMed:10606845, ECO:0000269PubMed:10839714, ECO:0000269PubMed:11359398, ECO:0000269PubMed:11886499, ECO:0000269PubMed:7539673}. Note=The disease is caused by mutations affecting the gene represented in this entry.Keratoderma, palmoplantar, non-epidermolytic, focal (FNEPPK) [MIM:613000]: A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present. {ECO:0000269PubMed:8595410}. Note=The disease is caused by mutations affecting the gene represented in this entry.Unilateral palmoplantar verrucous nevus (UPVN) [MIM:144200]: UPVN is characterized by a localized epidermolytic hyperkeratosis in parts of the right palm and the right sole, following the lines of Blaschko. {ECO:0000269PubMed:10844556}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Tissue Specificity

Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007568	aging
GO:0008283	cell proliferation
GO:0008544	epidermis development
GO:0030336	negative regulation of cell migration
GO:0042633	hair cycle
GO:0045104	intermediate filament cytoskeleton organization