Version 5.4
Homo sapiens Gene: MYF6
Summary
InnateDB Gene IDBG-49614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYF6
Gene Name myogenic factor 6 (herculin)
Synonyms bHLHc4; CNM3; MRF4; myf-6
Species Homo sapiens
Ensembl Gene ENSG00000111046
Encoded Proteins
IDBP-49616
myogenic factor 6 (herculin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:80707498-80709474
Strand Forward strand
Band q21.31
Transcripts
ENST00000228641 ENSP00000228641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0001756 somitogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0035914 skeletal muscle cell differentiation
GO:0042692 muscle cell differentiation
GO:0042693 muscle cell fate commitment
GO:0043403 skeletal muscle tissue regeneration
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051149 positive regulation of muscle cell differentiation
GO:0060415 muscle tissue morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035923
View Gene Order
ENSBTAG00000014003
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_21303
Myogenesis pathway
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt P23409
TrEMBL
UniProt Splice Variant
Entrez Gene 4618
UniGene Hs.35937 Hs.597954
RefSeq NM_002469
HUGO HGNC:7566
OMIM 159991
CCDS CCDS9019
HPRD 01169
IMGT
EMBL AK313287 BC017834 CH471054 CR407641 CR541763 X52011
GenPept AAH17834 BAG36095 CAA36260 CAG28569 CAG46563 EAW97367
RNA Seq Atlas 4618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca