Homo sapiens Gene: CD6
Summary
InnateDB Gene IDBG-49617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD6
Gene Name CD6 molecule
Synonyms TP120
Species Homo sapiens
Ensembl Gene ENSG00000013725
Encoded Proteins
CD6 molecule
CD6 molecule
CD6 molecule
CD6 molecule
CD6 molecule
CD6 molecule
CD6 molecule
CD6 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60971680-61020377
Strand Forward strand
Band q12.2
Transcripts
ENST00000313421 ENSP00000323280
ENST00000352009 ENSP00000340628
ENST00000344931 ENSP00000340334
ENST00000419282
ENST00000433107 ENSP00000410638
ENST00000452451 ENSP00000390676
ENST00000505761
ENST00000542254 ENSP00000443748
ENST00000545105
ENST00000545320
ENST00000542157 ENSP00000440055
ENST00000538288
ENST00000541964
ENST00000538611 ENSP00000443747
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0007155 cell adhesion
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.734800
RefSeq NM_001254750 NM_001254751 NM_006725 XM_006718738 XM_006718739 XM_006718740
HUGO
OMIM
CCDS CCDS58137 CCDS58138 CCDS7999
HPRD 01724
IMGT
EMBL
GenPept
RNA Seq Atlas