InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD6

Summary

InnateDB Protein

IDBP-49623.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD6

Protein Name

CD6 molecule

Synonyms

TP120;

Species

Homo sapiens

Ensembl Protein

ENSP00000340628

InnateDB Gene

IDBG-49617 (CD6)

Protein Structure

UniProt Annotation

Function

Involved in cell adhesion. Binds to CD166.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17371992}; Single-pass type I membrane protein {ECO:0000269PubMed:17371992}.

Disease Associations

Tissue Specificity

Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR017448 SRCR-like domain

PFAM

PF00530

PRINTS

PR00258

PIRSF

SMART

SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30203

PhosphoSite

PhosphoSite-P30203

TrEMBL

UniProt Splice Variant

Entrez Gene

923

UniGene

Hs.734800

RefSeq

NP_001241679

HUGO

HGNC:1691

OMIM

186720

CCDS

CCDS58138

HPRD

01724

IMGT

EMBL

AP003721 DQ786329 DQ786330 U66142 U66143 U66144 U66145 U66146 X60992

GenPept

AAC51161 AAC51162 AAC51163 AAC51164 AAC51165 ABH04237 ABH04238 CAA43306