Version 5.4
Homo sapiens Gene: SLC3A1
Summary
InnateDB Gene IDBG-49716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC3A1
Gene Name solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
Synonyms ATR1; CSNU1; D2H; NBAT; RBAT
Species Homo sapiens
Ensembl Gene ENSG00000138079
Encoded Proteins
IDBP-49720
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293705
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293707
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293703
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293700
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293698
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293691
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-293687
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-374369
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
IDBP-807948
solute carrier family 3 (amino acid transporter heavy chain), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:44275458-44321494
Strand Forward strand
Band p21
Transcripts
ENST00000260649 ENSP00000260649
ENST00000409387 ENSP00000387308
ENST00000409229 ENSP00000386620
ENST00000409741 ENSP00000386954
ENST00000410056 ENSP00000387337
ENST00000409380 ENSP00000386709
ENST00000409740 ENSP00000386677
ENST00000409294 ENSP00000386852
ENST00000427285 ENSP00000391642
ENST00000611973 ENSP00000483618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015174 basic amino acid transmembrane transporter activity
GO:0015184 L-cystine transmembrane transporter activity
GO:0043169 cation binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0005975 carbohydrate metabolic process
GO:0006520 cellular amino acid metabolic process
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015802 basic amino acid transport
GO:0015811 L-cystine transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0005774 vacuolar membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024131
View Gene Order
ENSBTAG00000017421
Not yet available
Pathways
NETPATH
REACTOME
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q07837
TrEMBL
UniProt Splice Variant
Entrez Gene 6519
UniGene Hs.112916 Hs.605351
RefSeq NM_000341
HUGO HGNC:11025
OMIM 104614
CCDS CCDS1819
HPRD 00090
IMGT
EMBL AB033549 AC013717 AK223146 AK289636 BC022386 BC093624 BC093626 D82326 DQ023512 DQ023513 DQ023514 DQ023515 DQ023516 DQ023517 L11696 M95548 U60810 U60811 U60812 U60813 U60814 U60815 U60816 U60818 U60819
GenPept AAA35500 AAA81778 AAB39829 AAH22386 AAH93624 AAH93626 AAX88955 AAY89643 AAY89644 AAY89645 AAY89646 AAY89647 AAY89648 BAA11541 BAB16841 BAD96866 BAF82325
RNA Seq Atlas 6519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca