Homo sapiens Gene: PPFIA2

Summary
InnateDB Gene IDBG-49741.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PPFIA2
Gene Name protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139220
Encoded Proteins
IDBP-49743 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-294891 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-380709 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-590789 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-596142 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-593625 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-603869 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-583611 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-584536 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-591948 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-603343 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-596649 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-594153 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-585187 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-590453 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-603345 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-586785 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-595568 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
IDBP-590612 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Entrez Gene
Summary The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12: 81652045-82153332
Strand Reverse strand
Band q21.31
Transcripts
ENST00000333447  ENSP00000327416
ENST00000407050  ENSP00000385093
ENST00000443686  ENSP00000388373
ENST00000545296 
ENST00000541570  ENSP00000438337
ENST00000551461  ENSP00000449821
ENST00000550359  ENSP00000447273
ENST00000548586  ENSP00000449338
ENST00000552948  ENSP00000447868
ENST00000550018  ENSP00000447189
ENST00000551147  ENSP00000449524
ENST00000547180 
ENST00000549344 
ENST00000549917 
ENST00000553058  ENSP00000448941
ENST00000548670  ENSP00000447792
ENST00000548790  ENSP00000446555
ENST00000548453 
ENST00000552020 
ENST00000551442  ENSP00000449469
ENST00000547623  ENSP00000447918
ENST00000552006 
ENST00000547273 
ENST00000550798 
ENST00000541017  ENSP00000445532
ENST00000549396  ENSP00000450337
ENST00000550584  ENSP00000449558
ENST00000549325  ENSP00000450298
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein‑Protein  16
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0000166 nucleotide binding
GO:0005515 protein binding
Biological Process
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000053825 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000003036 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O75334 
TrEMBL B3KVT5 B7Z3U9 B7Z663 E7ETG6 F8VU88 F8VWG6 F8VWR9 F8VYK7 F8W1Y8 G3V200 J3KNM3
UniProt Splice Variant
Entrez Gene 8499 
UniGene Hs.506216 Hs.629519 Hs.662544 Hs.737103 Hs.737278
RefSeq NM_001220473  NM_001220474  NM_001220475  NM_001220476  NM_001220477  NM_001220478  NM_001220479  NM_001220480  NM_003625 
HUGO 9246 
OMIM 603143
CCDS CCDS55850  CCDS55851  CCDS55852  CCDS55853  CCDS55854  CCDS55855  CCDS55856  CCDS55857 
HPRD 04392
IMGT
EMBL AC011316 AC069228 AC078920 AC079363 AC079408 AF034799 AK123372 AK126971 AK296380 AK299853 BC104912 BC143485 CH471054
GenPept AAC26100  AAI04913  AAI43486  BAG53897  BAG54412  BAH12335  BAH13149  EAW97374 
ImmGen PPFIA2 (murine) 
RNA Seq Atlas 8499