Homo sapiens Gene: PPFIA2
Summary
InnateDB Gene IDBG-49741.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PPFIA2
Gene Name protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139220
Encoded Proteins
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:81652045-82153332
Strand Reverse strand
Band q21.31
Transcripts
ENST00000333447 ENSP00000327416
ENST00000407050 ENSP00000385093
ENST00000443686 ENSP00000388373
ENST00000545296
ENST00000541570 ENSP00000438337
ENST00000551461 ENSP00000449821
ENST00000550359 ENSP00000447273
ENST00000548586 ENSP00000449338
ENST00000552948 ENSP00000447868
ENST00000550018 ENSP00000447189
ENST00000551147 ENSP00000449524
ENST00000547180
ENST00000549344
ENST00000549917
ENST00000553058 ENSP00000448941
ENST00000548670 ENSP00000447792
ENST00000548790 ENSP00000446555
ENST00000548453
ENST00000552020
ENST00000551442 ENSP00000449469
ENST00000547623 ENSP00000447918
ENST00000552006
ENST00000547273
ENST00000550798
ENST00000541017 ENSP00000445532
ENST00000549396 ENSP00000450337
ENST00000550584 ENSP00000449558
ENST00000549325 ENSP00000450298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
Biological Process
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O75334
TrEMBL B3KVT5 B7Z3U9 B7Z663 E7ETG6 F8VU88 F8VWG6 F8VWR9 F8VYK7 F8W1Y8 G3V200 J3KNM3
UniProt Splice Variant
Entrez Gene 8499
UniGene Hs.506216 Hs.629519 Hs.662544 Hs.737103 Hs.737278
RefSeq NM_001220473 NM_001220474 NM_001220475 NM_001220476 NM_001220477 NM_001220478 NM_001220479 NM_001220480 NM_003625
HUGO 9246
OMIM 603143
CCDS CCDS55850 CCDS55851 CCDS55852 CCDS55853 CCDS55854 CCDS55855 CCDS55856 CCDS55857
HPRD 04392
IMGT
EMBL AC011316 AC069228 AC078920 AC079363 AC079408 AF034799 AK123372 AK126971 AK296380 AK299853 BC104912 BC143485 CH471054
GenPept AAC26100 AAI04913 AAI43486 BAG53897 BAG54412 BAH12335 BAH13149 EAW97374
ImmGen PPFIA2 (murine)
RNA Seq Atlas 8499