Version 5.4
Homo sapiens Gene: SIX3
Summary
InnateDB Gene IDBG-49977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIX3
Gene Name SIX homeobox 3
Synonyms HPE2
Species Homo sapiens
Ensembl Gene ENSG00000138083
Encoded Proteins
IDBP-49979
SIX homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:44941898-44946077
Strand Forward strand
Band p21
Transcripts
ENST00000260653 ENSP00000260653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001654 eye development
GO:0006366 transcription from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0007420 brain development
GO:0007601 visual perception
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021797 forebrain anterior/posterior pattern specification
GO:0030178 negative regulation of Wnt signaling pathway
GO:0043010 camera-type eye development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048512 circadian behavior
GO:0060235 lens induction in camera-type eye
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038805
View Gene Order
ENSBTAG00000027017
Not yet available
Cross-References
SwissProt O95343
TrEMBL A0PJI2 Q9NSJ2
UniProt Splice Variant
Entrez Gene 6496
UniGene Hs.567336
RefSeq NM_005413
HUGO HGNC:10889
OMIM 603714
CCDS CCDS1821
HPRD
IMGT
EMBL AC012354 AF049339 AF083891 AF092047 AJ012611 AL162671 BC030289 CH471053
GenPept AAD11939 AAD15753 AAD51091 AAH30289 AAX93283 CAB42539 CAB83141 EAX00267 EAX00268
RNA Seq Atlas 6496

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca