Mus musculus Gene: Six3

Summary
InnateDB Gene IDBG-201024.6
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol Six3
Gene Name sine oculis-related homeobox 3
Synonyms E130112M24Rik; Six3a; Six3alpha; Six3b; Six3beta
Species Mus musculus
Ensembl Gene ENSMUSG00000038805
Encoded Proteins
IDBP-537497 sine oculis-related homeobox 3 homolog (Drosophila)
IDBP-714587
IDBP-713096
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138083:
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 85613608-85631813
Strand Forward strand
Band E4
Transcripts
ENSMUST00000162695  ENSMUSP00000125169
ENSMUST00000176081  ENSMUSP00000135312
ENSMUST00000175898  ENSMUSP00000135677
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein‑Protein  8
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001654 eye development
GO:0006355 regulation of transcription, DNA-dependent
GO:0006606 protein import into nucleus
GO:0007420 brain development
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021797 forebrain anterior/posterior pattern specification
GO:0030178 negative regulation of Wnt receptor signaling pathway
GO:0043010 camera-type eye development
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048512 circadian behavior
GO:0060235 lens induction in camera-type eye
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000138083 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000027017 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q62233 
TrEMBL H3BKA3 Q52KB8
UniProt Splice Variant
Entrez Gene 20473 
UniGene Mm.364933 Mm.370208 Mm.428113 Mm.437682
RefSeq NM_011381 
OMIM
CCDS CCDS50203 
HPRD
IMGT
MGI ID MGI:102764 
MGI Symbol Six3
EMBL AC166821 BC094426 BC098096 D83144 D83145 X90871
GenPept AAH94426  AAH98096  BAA11822  BAA11823  CAA62379 
ImmGen Six3 (murine) 
RNA Seq Atlas 20473