Version 5.4
Homo sapiens Gene: DAGLA
Summary
InnateDB Gene IDBG-50255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAGLA
Gene Name diacylglycerol lipase, alpha
Synonyms C11orf11; DAGL(ALPHA); DAGLALPHA; NSDDR
Species Homo sapiens
Ensembl Gene ENSG00000134780
Encoded Proteins
IDBP-50257
diacylglycerol lipase, alpha
IDBP-588191
diacylglycerol lipase, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61680433-61747001
Strand Forward strand
Band q12.2
Transcripts
ENST00000257215 ENSP00000257215
ENST00000540717 ENSP00000440264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0007405 neuroblast proliferation
GO:0007596 blood coagulation
GO:0008219 cell death
GO:0019369 arachidonic acid metabolic process
GO:0022008 neurogenesis
GO:0030168 platelet activation
GO:0042136 neurotransmitter biosynthetic process
GO:0046340 diacylglycerol catabolic process
GO:0071926 endocannabinoid signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035735
View Gene Order
ENSBTAG00000013942
Not yet available
Pathways
NETPATH
REACTOME
REACT_19308
Arachidonate production from DAG pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.241564
RefSeq NM_006133 XM_005274230
HUGO
OMIM
CCDS CCDS31578
HPRD 07092
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca