Homo sapiens Gene: IL15RA | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-50371.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | IL15RA | ||||||||||||||||||||||
Gene Name | interleukin 15 receptor, alpha | ||||||||||||||||||||||
Synonyms | CD215 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000134470 | ||||||||||||||||||||||
Encoded Proteins |
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
interleukin 15 receptor, alpha
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:5937569-5978187 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p15.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Intestinal immune network for IgA production pathway
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INOH |
JAK STAT pathway and regulation pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | K9N163 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 3601 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001243539 NM_001256765 NM_002189 NM_172200 | ||||||||||||||||||||||
HUGO | HGNC:5978 | ||||||||||||||||||||||
OMIM | 601070 | ||||||||||||||||||||||
CCDS | CCDS58069 CCDS7074 CCDS7075 CCDS73065 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | JX987305 | ||||||||||||||||||||||
GenPept | AFY11388 | ||||||||||||||||||||||
RNA Seq Atlas | 3601 | ||||||||||||||||||||||