Version 5.4
Homo sapiens Gene: IL15RA
Summary
InnateDB Gene IDBG-50371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL15RA
Gene Name interleukin 15 receptor, alpha
Synonyms CD215
Species Homo sapiens
Ensembl Gene ENSG00000134470
Encoded Proteins
IDBP-50375
interleukin 15 receptor, alpha
IDBP-50381
interleukin 15 receptor, alpha
IDBP-235759
interleukin 15 receptor, alpha
IDBP-235763
interleukin 15 receptor, alpha
IDBP-235765
interleukin 15 receptor, alpha
IDBP-235767
interleukin 15 receptor, alpha
IDBP-235769
interleukin 15 receptor, alpha
IDBP-363967
interleukin 15 receptor, alpha
IDBP-364006
interleukin 15 receptor, alpha
IDBP-364020
interleukin 15 receptor, alpha
IDBP-364023
interleukin 15 receptor, alpha
IDBP-596395
interleukin 15 receptor, alpha
IDBP-594845
interleukin 15 receptor, alpha
IDBP-604072
interleukin 15 receptor, alpha
IDBP-604071
interleukin 15 receptor, alpha
IDBP-812043
interleukin 15 receptor, alpha
IDBP-812045
interleukin 15 receptor, alpha
IDBP-812046
interleukin 15 receptor, alpha
IDBP-812047
interleukin 15 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:5937569-5978187
Strand Reverse strand
Band p15.1
Transcripts
ENST00000379977 ENSP00000369312
ENST00000379974
ENST00000379972
ENST00000379971 ENSP00000369306
ENST00000397255 ENSP00000380426
ENST00000397251 ENSP00000380423
ENST00000397250 ENSP00000380422
ENST00000397248 ENSP00000380421
ENST00000397246 ENSP00000380420
ENST00000435171 ENSP00000393612
ENST00000447291 ENSP00000405128
ENST00000429135 ENSP00000395113
ENST00000453922 ENSP00000405107
ENST00000534292
ENST00000532948
ENST00000528354 ENSP00000435454
ENST00000532039 ENSP00000432691
ENST00000530685 ENSP00000435995
ENST00000525219 ENSP00000431529
ENST00000622442 ENSP00000480949
ENST00000620345 ENSP00000479839
ENST00000620865 ENSP00000478525
ENST00000618528 ENSP00000479938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0008283 cell proliferation
GO:0010977 negative regulation of neuron projection development
GO:0019221 cytokine-mediated signaling pathway
GO:0031667 response to nutrient levels
GO:0032825 positive regulation of natural killer cell differentiation
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023206
View Gene Order
ENSBTAG00000006078
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL K9N163
UniProt Splice Variant
Entrez Gene 3601
UniGene
RefSeq NM_001243539 NM_001256765 NM_002189 NM_172200
HUGO HGNC:5978
OMIM 601070
CCDS CCDS58069 CCDS7074 CCDS7075 CCDS73065
HPRD
IMGT
EMBL JX987305
GenPept AFY11388
RNA Seq Atlas 3601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca