InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DUSP6

Summary

InnateDB Gene

IDBG-50524.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP6

Gene Name

dual specificity phosphatase 6

Synonyms

HH19; MKP3; PYST1

Species

Homo sapiens

Ensembl Gene

ENSG00000139318

Encoded Proteins

IDBP-50526

dual specificity phosphatase 6

IDBP-50528

dual specificity phosphatase 6

IDBP-590528

dual specificity phosphatase 6

IDBP-590872

dual specificity phosphatase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:89347232-89353271

Strand

Reverse strand

Band

q21.33

Transcripts

ENST00000279488	ENSP00000279488
ENST00000308385	ENSP00000307835
ENST00000547291	ENSP00000449838
ENST00000547140
ENST00000548755	ENSP00000446858

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	14 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001933	negative regulation of protein phosphorylation
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006470	protein dephosphorylation
GO:0009953	dorsal/ventral pattern formation
GO:0010033	response to organic substance
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0016311	dephosphorylation
GO:0030154	cell differentiation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0042493	response to drug
GO:0042663	regulation of endodermal cell fate specification
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051403	stress-activated MAPK cascade
GO:0051409	response to nitrosative stress
GO:0060420	regulation of heart growth
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070848	response to growth factor