InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP6

Summary

InnateDB Protein

IDBP-590528.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP6

Protein Name

dual specificity phosphatase 6

Synonyms

HH19; MKP3; PYST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000449838

InnateDB Gene

IDBG-50524 (DUSP6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	14 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700
PR01764

PIRSF

PIRSF000939

SMART

SM00194
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References