Version 5.4
Homo sapiens Gene: DLL3
Summary
InnateDB Gene IDBG-50586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLL3
Gene Name delta-like 3 (Drosophila)
Synonyms SCDO1
Species Homo sapiens
Ensembl Gene ENSG00000090932
Encoded Proteins
IDBP-50588
delta-like 3 (Drosophila)
IDBP-50590
delta-like 3 (Drosophila)
IDBP-764306
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39498895-39508481
Strand Forward strand
Band q13.2
Transcripts
ENST00000205143 ENSP00000205143
ENST00000356433 ENSP00000348810
ENST00000596614 ENSP00000471688
ENST00000600579
ENST00000600437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001756 somitogenesis
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0007386 compartment pattern specification
GO:0009888 tissue development
GO:0048339 paraxial mesoderm development
GO:0050768 negative regulation of neurogenesis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003436
View Gene Order
ENSBTAG00000010483
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
hsa04330
Notch signaling pathway pathway
INOH
INOH website
Notch signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.127792
RefSeq NM_016941 NM_203486
HUGO
OMIM
CCDS CCDS12537 CCDS12538
HPRD 04140
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca