Homo sapiens Gene: DLL3

Summary
InnateDB Gene IDBG-50586.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol DLL3
Gene Name delta-like 3 (Drosophila)
Synonyms SCDO1
Species Homo sapiens
Ensembl Gene ENSG00000090932
Encoded Proteins
IDBP-50588 delta-like 3 (Drosophila)
IDBP-50590 delta-like 3 (Drosophila)
IDBP-764306
Entrez Gene
Summary This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 39989535-39999121
Strand Forward strand
Band q13.2
Transcripts
ENST00000205143  ENSP00000205143
ENST00000356433  ENSP00000348810
ENST00000596614  ENSP00000471688
ENST00000600579 
ENST00000600437 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001756 somitogenesis
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0007386 compartment pattern specification
GO:0007417 central nervous system development
GO:0009888 tissue development
GO:0045746 negative regulation of Notch signaling pathway
GO:0048339 paraxial mesoderm development
GO:0048712 negative regulation of astrocyte differentiation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
Cellular Component
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000003436 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000010483 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
NetPath_3 Notch pathway
REACTOME
KEGG
hsa04330  Notch signaling pathway
INOH
INOH website GPCR signaling
INOH website Notch signaling pathway
PID BIOCARTA
PID NCI
notch_pathway Notch signaling pathway
Cross-References
SwissProt Q9NYJ7 
TrEMBL E9PFG2
UniProt Splice Variant
Entrez Gene 10683 
UniGene Hs.127792
RefSeq NM_016941  NM_203486 
HUGO 2909 
OMIM 602768
CCDS CCDS12537  CCDS12538 
HPRD 04140
IMGT
EMBL AC011500 AF241367 AF241368 AF241369 AF241370 AF241371 AF241372 AF241373 BC000218
GenPept AAF62542  AAH00218 
ImmGen DLL3 (murine) 
RNA Seq Atlas 10683