Version 5.4
Homo sapiens Gene: QTRTD1
Summary
InnateDB Gene IDBG-50638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QTRTD1
Gene Name queuine tRNA-ribosyltransferase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151576
Encoded Proteins
IDBP-50640
queuine tRNA-ribosyltransferase domain containing 1
IDBP-484197
queuine tRNA-ribosyltransferase domain containing 1
IDBP-473959
queuine tRNA-ribosyltransferase domain containing 1
IDBP-474730
queuine tRNA-ribosyltransferase domain containing 1
IDBP-477506
queuine tRNA-ribosyltransferase domain containing 1
IDBP-473934
queuine tRNA-ribosyltransferase domain containing 1
IDBP-476472
queuine tRNA-ribosyltransferase domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:114005833-114088422
Strand Forward strand
Band q13.31
Transcripts
ENST00000281273 ENSP00000281273
ENST00000472599 ENSP00000420806
ENST00000485050 ENSP00000420682
ENST00000466050
ENST00000488665
ENST00000479882 ENSP00000418056
ENST00000493014 ENSP00000419169
ENST00000490183
ENST00000460163
ENST00000482307 ENSP00000419655
ENST00000466870
ENST00000467703
ENST00000462869
ENST00000483272
ENST00000495782
ENST00000462966 ENSP00000418180
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0008479 queuine tRNA-ribosyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008616 queuosine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022704
View Gene Order
ENSBTAG00000004977
Not yet available
Cross-References
SwissProt Q9H974
TrEMBL
UniProt Splice Variant
Entrez Gene 79691
UniGene Hs.477162
RefSeq NM_001256835 XM_005247769 XM_006713744 NM_001256836 NM_001256837 NM_024638 XM_005247770
HUGO HGNC:25771
OMIM
CCDS CCDS58844 CCDS33828 CCDS58845 CCDS58846
HPRD 17944
IMGT
EMBL AC092896 AC128687 AK023022 AK296938 AK299313 AL833709 BC034559 BC039265 CH471052 CR457296
GenPept AAH34559 AAH39265 BAB14361 BAH12458 BAH12998 CAG33577 EAW79613
RNA Seq Atlas 79691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca