InnateDB Protein
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IDBP-50640.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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QTRTD1
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Protein Name
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queuine tRNA-ribosyltransferase domain containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000281273
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InnateDB Gene
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IDBG-50638 (QTRTD1)
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Protein Structure
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Function |
Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). {ECO:0000255HAMAP- Rule:MF_03043}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03043}. Mitochondrion {ECO:0000255HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255HAMAP-Rule:MF_03043}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002616
tRNA-guanine(15) transglycosylase-like
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PFAM |
PF01702
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H974
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PhosphoSite |
PhosphoSite-Q9H974
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79691
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UniGene |
Hs.477162
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RefSeq |
NP_078914
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HUGO |
HGNC:25771
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OMIM |
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CCDS |
CCDS33828
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HPRD |
17944
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IMGT |
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EMBL |
AC092896
AC128687
AK023022
AK296938
AK299313
AL833709
BC034559
BC039265
CH471052
CR457296
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GenPept |
AAH34559
AAH39265
BAB14361
BAH12458
BAH12998
CAG33577
EAW79613
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