InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LUM

Summary

InnateDB Gene

IDBG-50825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LUM

Gene Name

lumican

Synonyms

LDC; SLRR2D

Species

Homo sapiens

Ensembl Gene

ENSG00000139329

Encoded Proteins

IDBP-50827

lumican

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23358433

[Mus musculus] Lum facilitates early innate immune responses and orchestrates bacterial clearance and inflammation resolution in the cornea.

Entrez Gene

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:91102629-91111831

Strand

Reverse strand

Band

q21.33

Transcripts

ENST00000266718	ENSP00000266718
ENST00000548071
ENST00000546642

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007601	visual perception
GO:0014070	response to organic cyclic compound
GO:0018146	keratan sulfate biosynthetic process
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0042340	keratan sulfate catabolic process
GO:0044281	small molecule metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:0070848	response to growth factor

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005583	fibrillar collagen trimer
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome