InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LUM

Summary

InnateDB Protein

IDBP-50827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LUM

Protein Name

lumican

Synonyms

LDC; SLRR2D;

Species

Homo sapiens

Ensembl Protein

ENSP00000266718

InnateDB Gene

IDBG-50825 (LUM)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Cornea and other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007601	visual perception
GO:0014070	response to organic cyclic compound
GO:0018146	keratan sulfate biosynthetic process
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0042340	keratan sulfate catabolic process
GO:0044281	small molecule metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:0070848	response to growth factor

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005583	fibrillar collagen trimer
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome