Homo sapiens Gene: FREM1
Summary
InnateDB Gene IDBG-50859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FREM1
Gene Name FRAS1 related extracellular matrix 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164946
Encoded Proteins
FRAS1 related extracellular matrix 1
FRAS1 related extracellular matrix 1
FRAS1 related extracellular matrix 1
FRAS1 related extracellular matrix 1
FRAS1 related extracellular matrix 1
Protein Structure
InnateDB Annotation
Summary
FREM1 selectively amplifies NF-kB responses, such as cell survival and inflammatory responses, through changes in receptor conformation and adapter protein recruitment.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Frem1 selectively amplifies NF-kB responses, such as cell survival and inflammatory responses, through changes in receptor conformation and adapter protein recruitment. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:14734666-14910995
Strand Reverse strand
Band p22.3
Transcripts
ENST00000380894 ENSP00000370278
ENST00000380880 ENSP00000370262
ENST00000380875 ENSP00000370257
ENST00000422223 ENSP00000412940
ENST00000427623 ENSP00000412597
ENST00000486223
ENST00000485068
ENST00000466679
ENST00000497634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0007154 cell communication
GO:0007160 cell-matrix adhesion
GO:0045087 innate immune response (InnateDB)
GO:0097094 craniofacial suture morphogenesis
Cellular Component
GO:0005604 basement membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q5H8C1
TrEMBL C9JT55 F8WE85
UniProt Splice Variant
Entrez Gene 158326
UniGene Hs.50850
RefSeq NM_001177704 NM_144966 XM_005251382 XM_005251383 XM_005251384 XM_006716723 XM_006716724 XM_006716725 XM_006716726 XM_006716727 XM_006716728 XM_006716729
HUGO HGNC:23399
OMIM 608944
CCDS CCDS47952 CCDS55293
HPRD 09865
IMGT
EMBL AB160987 AK058190 AL354672 AL390732 AL512643 BC031064 BX641104
GenPept AAH31064 BAB71709 BAD89015 CAE46048 CAH71826 CAH73848
ImmGen FREM1 (murine)
RNA Seq Atlas 158326