Bos taurus Gene: FREM1 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-630756.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | FREM1 | ||||||||||
Gene Name | FRAS1-related extracellular matrix protein 1 precursor | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000020141 | ||||||||||
Encoded Proteins |
FRAS1 related extracellular matrix 1
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
InnateDB Annotation from Orthologs | |||||||||||
Summary |
[Homo sapiens] FREM1 selectively amplifies NF-kB responses, such as cell survival and inflammatory responses, through changes in receptor conformation and adapter protein recruitment.
[Mus musculus] Frem1 selectively amplifies NF-kB responses, such as cell survival and inflammatory responses, through changes in receptor conformation and adapter protein recruitment. (Demonstrated in human)
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Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164946:
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 8:29353418-29504029 | ||||||||||
Strand | Forward strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | E1BN52 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 508018 | ||||||||||
UniGene | Bt.70226 | ||||||||||
RefSeq | NM_001192995 XM_005209921 | ||||||||||
HUGO | HGNC:23399 | ||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | DAAA02022402 DAAA02022403 DAAA02022404 DAAA02022405 | ||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 508018 | ||||||||||