Version 5.4
Homo sapiens Gene: HSD17B1
Summary
InnateDB Gene IDBG-51038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B1
Gene Name hydroxysteroid (17-beta) dehydrogenase 1
Synonyms EDH17B2; EDHB17; HSD17; SDR28C1
Species Homo sapiens
Ensembl Gene ENSG00000108786
Encoded Proteins
IDBP-51040
hydroxysteroid (17-beta) dehydrogenase 1
IDBP-758059
IDBP-761327
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42549214-42555213
Strand Forward strand
Band q21.2
Transcripts
ENST00000225929 ENSP00000225929
ENST00000587280
ENST00000585807 ENSP00000466799
ENST00000593215
ENST00000590299 ENSP00000465128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0060348 bone development
GO:0061370 testosterone biosynthetic process
GO:0071248 cellular response to metal ion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019301
View Gene Order
ENSBTAG00000047604
Not yet available
Pathways
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_11037
Estrogen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3292
UniGene Hs.640276 Hs.654385 Hs.656023 Hs.664047
RefSeq XM_006721859 NM_000413
HUGO HGNC:5210
OMIM 109684
CCDS CCDS11428
HPRD 00185
IMGT
EMBL
GenPept
RNA Seq Atlas 3292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca