InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MLX

Summary

InnateDB Gene

IDBG-51109.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLX

Gene Name

MLX, MAX dimerization protein

Synonyms

bHLHd13; MAD7; MXD7; TCFL4

Species

Homo sapiens

Ensembl Gene

ENSG00000108788

Encoded Proteins

IDBP-51111

MAX-like protein X

IDBP-51113

MAX-like protein X

IDBP-378890

MAX-like protein X

IDBP-757677

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:42567068-42573239

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000246912	ENSP00000246912
ENST00000346833	ENSP00000320913
ENST00000435881	ENSP00000416627
ENST00000591195
ENST00000592717
ENST00000585403
ENST00000590050
ENST00000590084
ENST00000586393
ENST00000588320
ENST00000591024	ENSP00000464697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006112	energy reserve metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0031325	positive regulation of cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017801

View Gene Order

ENSBTAG00000046670

Not yet available

Pathways

NETPATH

REACTOME

REACT_2122

ChREBP activates metabolic gene expression pathway

REACT_1505

Integration of energy metabolism pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.714749 Hs.732454

RefSeq

NM_170607 NM_198204 NM_198205

HUGO

OMIM

CCDS

CCDS11430 CCDS42341 CCDS45687

HPRD

04278

IMGT

EMBL

GenPept

RNA Seq Atlas