InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLX

Summary

InnateDB Protein

IDBP-51111.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLX

Protein Name

MAX-like protein X

Synonyms

bHLHd13; MAD7; MXD7; TCFL4;

Species

Homo sapiens

Ensembl Protein

ENSP00000246912

InnateDB Gene

IDBG-51109 (MLX)

Protein Structure

UniProt Annotation

Function

Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269PubMed:10593926, ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}.

Subcellular Localization

Isoform Alpha: Cytoplasm. Note=Found predominantly in the cytoplasm.Isoform Beta: Cytoplasm. Note=Found predominantly in the cytoplasm.Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. {ECO:0000269PubMed:10593926}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006112	energy reserve metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0031325	positive regulation of cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated