Version 5.4
Homo sapiens Gene: FGF1
Summary
InnateDB Gene IDBG-51235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF1
Gene Name fibroblast growth factor 1 (acidic)
Synonyms AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1
Species Homo sapiens
Ensembl Gene ENSG00000113578
Encoded Proteins
IDBP-51239
fibroblast growth factor 1 (acidic)
IDBP-51241
fibroblast growth factor 1 (acidic)
IDBP-51243
fibroblast growth factor 1 (acidic)
IDBP-51245
fibroblast growth factor 1 (acidic)
IDBP-241473
fibroblast growth factor 1 (acidic)
IDBP-295415
fibroblast growth factor 1 (acidic)
IDBP-379194
fibroblast growth factor 1 (acidic)
IDBP-379195
fibroblast growth factor 1 (acidic)
IDBP-379200
fibroblast growth factor 1 (acidic)
IDBP-812355
fibroblast growth factor 1 (acidic)
IDBP-812357
fibroblast growth factor 1 (acidic)
IDBP-812358
fibroblast growth factor 1 (acidic)
IDBP-812359
fibroblast growth factor 1 (acidic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142592178-142698070
Strand Reverse strand
Band q31.3
Transcripts
ENST00000378046 ENSP00000367285
ENST00000337706 ENSP00000338548
ENST00000360966 ENSP00000354231
ENST00000359370 ENSP00000352329
ENST00000394496 ENSP00000378005
ENST00000407758 ENSP00000383969
ENST00000419524 ENSP00000396195
ENST00000441680 ENSP00000404742
ENST00000411960 ENSP00000399458
ENST00000489937
ENST00000494344
ENST00000494579
ENST00000621536 ENSP00000480791
ENST00000619447 ENSP00000480980
ENST00000610990 ENSP00000481868
ENST00000612258 ENSP00000479024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0030544 Hsp70 protein binding
GO:0044548 S100 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001759 organ induction
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0034605 cellular response to heat
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060681 branch elongation involved in ureteric bud branching
GO:0072163 mesonephric epithelium development
GO:1902533 positive regulation of intracellular signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036585
View Gene Order
ENSBTAG00000005198
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_21374
SHC-mediated cascade pathway
REACT_21270
PI-3K cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9416
FGFR2b ligand binding and activation pathway
REACT_9413
FGFR2c ligand binding and activation pathway
REACT_9508
FGFR3b ligand binding and activation pathway
REACT_9510
FGFR3c ligand binding and activation pathway
REACT_9515
FGFR1c ligand binding and activation pathway
REACT_9400
FGFR1b ligand binding and activation pathway
REACT_9452
FGFR4 ligand binding and activation pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120863
Activated point mutants of FGFR2 pathway
REACT_121153
Signaling by activated point mutants of FGFR1 pathway
REACT_121337
Signaling by activated point mutants of FGFR3 pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_121249
Signaling by FGFR3 mutants pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_9439
FGFR3 ligand binding and activation pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_121155
Signaling by FGFR2 mutants pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_9390
FGFR2 ligand binding and activation pathway
REACT_9396
FGFR ligand binding and activation pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_9483
FGFR1 ligand binding and activation pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.483635 Hs.596951 Hs.742465
RefSeq NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137 XM_005268390 XM_006714762
HUGO
OMIM
CCDS CCDS4275 CCDS4276
HPRD 00567
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca