InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF1

Summary

InnateDB Protein

IDBP-812355.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF1

Protein Name

fibroblast growth factor 1 (acidic)

Synonyms

AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000480791

InnateDB Gene

IDBG-51235 (FGF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0030544	Hsp70 protein binding
GO:0044548	S100 protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001759	organ induction
GO:0001934	positive regulation of protein phosphorylation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009653	anatomical structure morphogenesis
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0034605	cellular response to heat
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051781	positive regulation of cell division
GO:0060681	branch elongation involved in ureteric bud branching
GO:0072163	mesonephric epithelium development
GO:1902533	positive regulation of intracellular signal transduction

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005938	cell cortex