InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LHCGR

Summary

InnateDB Gene

IDBG-51399.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHCGR

Gene Name

luteinizing hormone/choriogonadotropin receptor

Synonyms

HHG; LCGR; LGR2; LH/CG-R; LH/CGR; LHR; LHRHR; LSH-R; ULG5

Species

Homo sapiens

Ensembl Gene

ENSG00000138039

Encoded Proteins

IDBP-51401

luteinizing hormone/choriogonadotropin receptor

IDBP-293446

luteinizing hormone/choriogonadotropin receptor

IDBP-293453

luteinizing hormone/choriogonadotropin receptor

IDBP-293451

luteinizing hormone/choriogonadotropin receptor

IDBP-375395

luteinizing hormone/choriogonadotropin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:48686775-48755730

Strand

Reverse strand

Band

p16.3

Transcripts

ENST00000294954	ENSP00000294954
ENST00000405626	ENSP00000386033
ENST00000401907	ENSP00000385406
ENST00000403273	ENSP00000385847
ENST00000428232	ENSP00000403748
ENST00000477576

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004964	luteinizing hormone receptor activity
GO:0035472	choriogonadotropin hormone receptor activity
GO:0038106	choriogonadotropin hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007190	activation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008584	male gonad development
GO:0030539	male genitalia development
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0042700	luteinizing hormone signaling pathway
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0050890	cognition
GO:0071371	cellular response to gonadotropin stimulus

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024107

View Gene Order

ENSBTAG00000016573

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_16942

Hormone ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

arf6_pathway

Arf6 signaling events

Cross-References

SwissProt

TrEMBL

E7ENI1 Q4ZFZ4

UniProt Splice Variant

Entrez Gene

3973

UniGene

Hs.468490

RefSeq

NM_000233 XM_005264309 XM_006712015

HUGO

HGNC:6585

OMIM

152790

CCDS

CCDS1842

HPRD

01073

IMGT

EMBL

AC073082 AC087816

GenPept

AAX88979

RNA Seq Atlas

3973