Version 5.4
| Homo sapiens Gene: COX17 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-51411.7 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | COX17 | ||||||||||||||||||
| Gene Name | cytochrome c oxidase assembly homolog 17 (yeast) | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000138495 | ||||||||||||||||||
| Encoded Proteins |
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008] Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92%% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 3:119654513-119677454 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.33 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Mitochondrial protein import pathway
Metabolism of proteins pathway
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| KEGG |
Oxidative phosphorylation pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q14061 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 10063 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_005694 | ||||||||||||||||||
| HUGO | HGNC:2264 | ||||||||||||||||||
| OMIM | 604813 | ||||||||||||||||||
| CCDS | CCDS2993 | ||||||||||||||||||
| HPRD | 05314 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF269243 AF269244 AK312143 BC010933 BC105280 BC108317 CH471052 L77701 | ||||||||||||||||||
| GenPept | AAA98114 AAF82569 AAH10933 AAI05281 AAI08318 BAG35079 EAW79545 EAW79547 EAW79548 EAW79550 EAW79551 | ||||||||||||||||||
| RNA Seq Atlas | 10063 | ||||||||||||||||||