InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COX17

Summary

InnateDB Gene

IDBG-632776.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX17

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002182

Encoded Proteins

IDBP-684425

COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138495:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92%% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:65024153-65031968

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002828

ENSBTAP00000002828

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0016531	copper chaperone activity

Biological Process

GO:0006825

copper ion transport

Cellular Component

GO:0005758

mitochondrial intermembrane space

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000138495

View Gene Order

ENSMUSG00000046516

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

REACT_247926

Metabolism of proteins pathway

REACT_199101

Mitochondrial protein import pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

mmu00190

Oxidative phosphorylation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F6QD94

UniProt Splice Variant

Entrez Gene

100295800

UniGene

RefSeq

XM_002684734 XM_003581702 XM_005196076 XM_005201375

HUGO

HGNC:2264

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02001548

GenPept

RNA Seq Atlas

100295800