Version 5.4
Homo sapiens Gene: GSK3B
Summary
InnateDB Gene IDBG-51663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSK3B
Gene Name glycogen synthase kinase 3 beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000082701
Encoded Proteins
IDBP-51665
glycogen synthase kinase 3 beta
IDBP-51667
glycogen synthase kinase 3 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17912008
GSK3B is a cytoplasmic serine/threonine protein kinase that regulates NF-kappaB activation and the proliferation and survival of pancreatic cancer cells.
PMID 17726008
GSK3B inhibits MEKK4 activity and prevents its activation of JNK and p38, thus controlling MEKK4 dimerization both positively and negatively by regulating its interaction with specific proteins.
PMID 20497256
GSK3B activation is accelerated by TLR4 which leads to deterioration of serum-deprivation-induced apoptosis and beta-arrestin 2 represents an inhibitory effect on the TLR4-mediated apoptotic cascade, through controlling the homeostasis of activation and inactivation of GSK3B.
PMID 21515258
GSK3B is a regulator of LPS-mediated septic shock. GSK3B deficiency results in the attenuation of endotoxemia. (Demonstrated in murine model)
PMID 22218715
GSK3B functions downstream of TLR2-stimulation to induce the expression of the monocyte chemoattractant protein 1, CCL2. (Demonstrated in mice)
PMID 26100021
Glycogen synthase kinase 3/CTNNB1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
InnateDB Annotation from Orthologs
Summary
PMID 21515258
[Mus musculus] Gsk3b is a regulator of LPS-mediated septic shock. Gsk3b deficiency results in the attenuation of endotoxemia.
PMID 22218715
[Mus musculus] Gsk3b functions downstream of Tlr2-stimulation to induce the expression of the monocyte chemoattractant protein 1, Ccl2.
PMID 26100021
[Mus musculus] Glycogen synthase kinase 3/Ctnnb1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
Entrez Gene
Summary The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:119821323-120094417
Strand Reverse strand
Band q13.33
Transcripts
ENST00000264235 ENSP00000264235
ENST00000316626 ENSP00000324806
ENST00000474830
ENST00000473886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 482 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 482 [view]
Protein-Protein 477 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008013 beta-catenin binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0034236 protein kinase A catalytic subunit binding
GO:0035255 ionotropic glutamate receptor binding
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0000320 re-entry into mitotic cell cycle
GO:0001837 epithelial to mesenchymal transition
GO:0001954 positive regulation of cell-matrix adhesion
GO:0005977 glycogen metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006983 ER overload response
GO:0007163 establishment or maintenance of cell polarity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007520 myoblast fusion
GO:0007623 circadian rhythm
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 organ morphogenesis
GO:0010226 response to lithium ion
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010977 negative regulation of neuron projection development
GO:0014043 negative regulation of neuron maturation
GO:0014902 myotube differentiation
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0021766 hippocampus development
GO:0030010 establishment of cell polarity
GO:0031333 negative regulation of protein complex assembly
GO:0031334 positive regulation of protein complex assembly
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032855 positive regulation of Rac GTPase activity
GO:0032886 regulation of microtubule-based process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0036016 cellular response to interleukin-3
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0044027 hypermethylation of CpG island
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046827 positive regulation of protein export from nucleus
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048168 regulation of neuronal synaptic plasticity
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051534 negative regulation of NFAT protein import into nucleus
GO:0060070 canonical Wnt signaling pathway
GO:0071109 superior temporal gyrus development
GO:0071260 cellular response to mechanical stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077 negative regulation of type B pancreatic cell development
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2000738 positive regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030426 growth cone
GO:0030529 ribonucleoprotein complex
GO:0030877 beta-catenin destruction complex
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043227 membrane-bounded organelle
GO:0043234 protein complex
GO:0044297 cell body
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000022812
View Gene Order
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_15
IL3 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_22
Leptin pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12564
AKT phosphorylates targets in the cytosol pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_19271
Semaphorin interactions pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_200819
Cellular response to heat stress pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04360
Axon guidance pathway
hsa05213
Endometrial cancer pathway
hsa05010
Alzheimer's disease pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
Hedgehog signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
lysophospholipid_pathway
LPA receptor mediated events
bmppathway
BMP receptor signaling
aurora_a_pathway
Aurora A signaling
reelinpathway
Reelin signaling pathway
ps1pathway
Presenilin action in Notch and Wnt signaling
lkb1_pathway
LKB1 signaling events
p53regulationpathway
p53 pathway
ilk_pathway
Integrin-linked kinase signaling
reg_gr_pathway
Glucocorticoid receptor regulatory network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
myc_pathway
C-MYC pathway
cdc42_pathway
CDC42 signaling events
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
ar_tf_pathway
Regulation of Androgen receptor activity
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614334 Hs.743698
RefSeq NM_001146156 NM_002093
HUGO
OMIM
CCDS CCDS2996 CCDS54628
HPRD 05418
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca