Version 5.4
Homo sapiens Gene: ITIH2
Summary
InnateDB Gene IDBG-51690.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH2
Gene Name inter-alpha-trypsin inhibitor heavy chain 2
Synonyms H2P; SHAP
Species Homo sapiens
Ensembl Gene ENSG00000151655
Encoded Proteins
IDBP-51692
inter-alpha (globulin) inhibitor H2
IDBP-51694
inter-alpha (globulin) inhibitor H2
IDBP-364887
inter-alpha (globulin) inhibitor H2
IDBP-813116
inter-alpha-trypsin inhibitor heavy chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:7703269-7749520
Strand Forward strand
Band p14
Transcripts
ENST00000358415 ENSP00000351190
ENST00000379587 ENSP00000368906
ENST00000429820 ENSP00000388826
ENST00000473227
ENST00000480387
ENST00000477751
ENST00000613369 ENSP00000477794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037254
View Gene Order
ENSBTAG00000014075
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3698
UniGene
RefSeq NM_002216
HUGO HGNC:6167
OMIM 146640
CCDS CCDS31141
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 3698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca