Version 5.4
Mus musculus Gene: Itih2
Summary
InnateDB Gene IDBG-135660.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itih2
Gene Name inter-alpha trypsin inhibitor, heavy chain 2
Synonyms AI747202; Intin2; Itih-2
Species Mus musculus
Ensembl Gene ENSMUSG00000037254
Encoded Proteins
IDBP-135662
inter-alpha trypsin inhibitor, heavy chain 2
IDBP-535451
inter-alpha trypsin inhibitor, heavy chain 2
IDBP-537651
inter-alpha trypsin inhibitor, heavy chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151655:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:10094593-10131396
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000042290 ENSMUSP00000046530
ENSMUST00000155809 ENSMUSP00000124636
ENSMUST00000161909 ENSMUSP00000124880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151655
View Gene Order
ENSBTAG00000014075
Not yet available
Cross-References
SwissProt
TrEMBL E0CX69 Q3UEG7
UniProt Splice Variant
Entrez Gene 16425
UniGene Mm.182043
RefSeq NM_010582
OMIM
CCDS CCDS15677
HPRD
IMGT
MGI ID MGI:96619
MGI Symbol Itih2
EMBL AK149533 AL772367
GenPept BAE28944
RNA Seq Atlas 16425

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca