InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNG3

Summary

InnateDB Gene

IDBG-51707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNG3

Gene Name

guanine nucleotide binding protein (G protein), gamma 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000162188

Encoded Proteins

IDBP-51709

guanine nucleotide binding protein (G protein), gamma 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62707658-62709201

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000294117

ENSP00000294117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0031702	type 1 angiotensin receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0044281	small molecule metabolic process
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000071658

View Gene Order

ENSBTAG00000002508

Not yet available

Pathways

NETPATH

REACTOME

REACT_23946

Prostacyclin signalling through prostacyclin receptor pathway

REACT_23876

Platelet homeostasis pathway

REACT_20653

ADP signalling through P2Y purinoceptor 12 pathway

REACT_19140

ADP signalling through P2Y purinoceptor 1 pathway

REACT_20647

Thromboxane signalling through TP receptor pathway

REACT_21384

Thrombin signalling through proteinase activated receptors (PARs) pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_19290

G beta:gamma signalling through PI3Kgamma pathway

REACT_19145

G beta:gamma signalling through PLC beta pathway

REACT_18407

G alpha (12/13) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_19333

G alpha (z) signalling events pathway

REACT_18377

Glucagon-type ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_15457

G-protein activation pathway

REACT_15295

Opioid Signalling pathway

REACT_25004

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway

REACT_25031

GABA B receptor activation pathway

REACT_21254

Presynaptic function of Kainate receptors pathway

REACT_75831

Activation of G protein gated Potassium channels pathway

REACT_18274

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway

REACT_18339

Adrenaline,noradrenaline inhibits insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1665

Glucagon signaling in metabolic regulation pathway

REACT_1505

Integration of energy metabolism pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_25199

GABA receptor activation pathway

REACT_75780

G protein gated Potassium channels pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_19388

G-protein beta:gamma signalling pathway

REACT_25330

Activation of GABAB receptors pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_75918

Inwardly rectifying K+ channels pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_75908

Potassium Channels pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21340

GPCR ligand binding pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

REACT_20524

Signal amplification pathway

REACT_23887

Aquaporin-mediated transport pathway

REACT_604

Hemostasis pathway

KEGG

hsa04742

Taste transduction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P63215

TrEMBL

UniProt Splice Variant

Entrez Gene

2785

UniGene

Hs.740581

RefSeq

NM_012202 XM_006718500 XM_006718501

HUGO

HGNC:4405

OMIM

608941

CCDS

CCDS8032

HPRD

IMGT

EMBL

AF087900 AF092129 AF188177 AF493871 AK311933 BC015563 CH471076

GenPept

AAD40371 AAF04567 AAH15563 AAM12585 AAP97199 BAG34874 EAW74082

RNA Seq Atlas

2785