InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNG3

Summary

InnateDB Protein

IDBP-51709.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNG3

Protein Name

guanine nucleotide binding protein (G protein), gamma 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000294117

InnateDB Gene

IDBG-51707 (GNG3)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0031702	type 1 angiotensin receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0044281	small molecule metabolic process
GO:0071377	cellular response to glucagon stimulus