Version 5.4
Homo sapiens Gene: STX5
Summary
InnateDB Gene IDBG-51952.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX5
Gene Name syntaxin 5
Synonyms SED5; STX5A
Species Homo sapiens
Ensembl Gene ENSG00000162236
Encoded Proteins
IDBP-51954
syntaxin 5
IDBP-51956
syntaxin 5
IDBP-241073
syntaxin 5
IDBP-376477
syntaxin 5
IDBP-594063
syntaxin 5
IDBP-597925
syntaxin 5
IDBP-600278
syntaxin 5
IDBP-585599
syntaxin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62806897-62832088
Strand Reverse strand
Band q12.3
Transcripts
ENST00000377897 ENSP00000367129
ENST00000294179 ENSP00000294179
ENST00000394690 ENSP00000378182
ENST00000431400 ENSP00000414289
ENST00000492066 ENSP00000434107
ENST00000491231 ENSP00000432748
ENST00000488303 ENSP00000435973
ENST00000486437 ENSP00000436495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006903 vesicle targeting
GO:0016192 vesicle-mediated transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0048280 vesicle fusion with Golgi apparatus
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031201 SNARE complex
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010110
View Gene Order
ENSBTAG00000009490
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654602
RefSeq NM_001244666 NM_003164
HUGO
OMIM
CCDS CCDS58140 CCDS8038
HPRD 04426
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca