Version 5.4
Homo sapiens Gene: HCLS1
Summary
InnateDB Gene IDBG-52066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCLS1
Gene Name hematopoietic cell-specific Lyn substrate 1
Synonyms CTTNL; HS1; lckBP1; p75
Species Homo sapiens
Ensembl Gene ENSG00000180353
Encoded Proteins
IDBP-52068
hematopoietic cell-specific Lyn substrate 1
IDBP-382921
hematopoietic cell-specific Lyn substrate 1
IDBP-480692
hematopoietic cell-specific Lyn substrate 1
IDBP-474732
hematopoietic cell-specific Lyn substrate 1
IDBP-482460
hematopoietic cell-specific Lyn substrate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:121631399-121660927
Strand Reverse strand
Band q13.33
Transcripts
ENST00000314583 ENSP00000320176
ENST00000428394 ENSP00000387645
ENST00000473883
ENST00000495491 ENSP00000418299
ENST00000464274 ENSP00000420507
ENST00000487290
ENST00000481314
ENST00000497391 ENSP00000419614
ENST00000488033
ENST00000468693
ENST00000491824
ENST00000479994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0009725 response to hormone
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030041 actin filament polymerization
GO:0030218 erythrocyte differentiation
GO:0030833 regulation of actin filament polymerization
GO:0030854 positive regulation of granulocyte differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022831
View Gene Order
ENSBTAG00000001009
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
NetPath_17
IL5 pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04530
Tight junction pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P14317
TrEMBL B4DQ69 E7EVW7 F8WDD5 F8WEZ6
UniProt Splice Variant
Entrez Gene 3059
UniGene Hs.14601 Hs.722506
RefSeq NM_001292041 NM_005335
HUGO HGNC:4844
OMIM 601306
CCDS CCDS3003
HPRD
IMGT
EMBL AC133750 AK298663 AK312750 BC016758 BT006824 CR456794 X16663
GenPept AAH16758 AAP35470 BAG35617 BAG60831 CAA34651 CAG33075
RNA Seq Atlas 3059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca