InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PFKL

Summary

InnateDB Gene

IDBG-5228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKL

Gene Name

phosphofructokinase, liver

Synonyms

ATP-PFK; PFK-B; PFK-L

Species

Homo sapiens

Ensembl Gene

ENSG00000141959

Encoded Proteins

IDBP-5232

phosphofructokinase, liver

IDBP-234149

phosphofructokinase, liver

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Phosphofructokinase (PFK) is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. Separate genes encode a muscle subunit (M) and a liver subunit (L). PFK from muscle is a homotetramer of M subunits, PFK from liver is a homotetramer of L-subunits, while PFK from platelets can be composed of any tetrameric combination of M and L subunits. The protein encoded by this gene represents the L subunit. Alternate splicing results in two transcript variants, one of which is a candidate for nonsense-mediated decay (NMD). [provided by RefSeq, Aug 2008]
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:44300051-44327376

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000349048	ENSP00000269848
ENST00000397961	ENSP00000381052
ENST00000496824
ENST00000466134
ENST00000491298
ENST00000474114
ENST00000498841
ENST00000460020
ENST00000467315
ENST00000460521
ENST00000495274

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003872	6-phosphofructokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding
GO:0070061	fructose binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0009749	response to glucose
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046835	carbohydrate phosphorylation
GO:0051259	protein oligomerization
GO:0051289	protein homotetramerization