InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFKL

Summary

InnateDB Protein

IDBP-5232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKL

Protein Name

phosphofructokinase, liver

Synonyms

ATP-PFK; PFK-B; PFK-L;

Species

Homo sapiens

Ensembl Protein

ENSP00000269848

InnateDB Gene

IDBG-5228 (PFKL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003872	6-phosphofructokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding
GO:0070061	fructose binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0009749	response to glucose
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046835	carbohydrate phosphorylation
GO:0051259	protein oligomerization
GO:0051289	protein homotetramerization