InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RYR3

Summary

InnateDB Gene

IDBG-5249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYR3

Gene Name

ryanodine receptor 3

Synonyms

RYR-3

Species

Homo sapiens

Ensembl Gene

ENSG00000198838

Encoded Proteins

IDBP-48915

ryanodine receptor 3

IDBP-364053

ryanodine receptor 3

IDBP-806486

ryanodine receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:33310962-33866102

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000389232	ENSP00000373884
ENST00000415757	ENSP00000399610
ENST00000557931
ENST00000558060
ENST00000559917
ENST00000559333
ENST00000560791
ENST00000622037	ENSP00000483166

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015278	calcium-release channel activity
GO:0048763	calcium-induced calcium release activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006941	striated muscle contraction
GO:0034220	ion transmembrane transport
GO:0051289	protein homotetramerization
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0071286	cellular response to magnesium ion
GO:0071313	cellular response to caffeine
GO:0071318	cellular response to ATP

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030314	junctional membrane complex
GO:0033017	sarcoplasmic reticulum membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000057378

View Gene Order

ENSBTAG00000025642

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa04020

Calcium signaling pathway pathway

hsa04970

Salivary secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.709373

RefSeq

NM_001036 NM_001243996

HUGO

OMIM

CCDS

CCDS45210 CCDS58351

HPRD

01620

IMGT

EMBL

GenPept

RNA Seq Atlas